NPC1 and nasopharyngeal carcinoma: Niemann-Picktype C (NPC) is a lysosomal storage disorder thataffects the body’s ability to transport and manage the cholesteroland lipids within the cells due to mutations in NPC1 or NPC2 genes.1,2 This buildup of lipids can cause extensive brain damage that complicateshead movement, walking, swallowing, an eventual loss of vision andhearing, as well causing cognitive and psychological complications.3−5 No cure is available for NPC with the only FDA approved treatmentbeing a combination of miglustat and arimoclomol (1 and 2, Figure 1).6−9