One of themolecules that has been associated with the burden of viral diseasesis TREM-1, mainly due to its role in amplifying the inflammatory response.Thus, we hypothesized that TREM-1 may be involved in NoV infection.Analysis of public transcriptomic data sets showed an increased expressionof Trem1 and Trem3 during murineNoV (MNoV) infection. Here, TREM1 is linked to infection.