As human NoV cultivation is a challenging task for referencelaboratories,this has negatively impacted in vitro studies anda broader understanding of its biology and pathophysiology.13 To minimize this drawback and despite its ownlimitations, experimental infection with MNoV has been used.14−16 Different MNoV strains (CW3, CR6, and S7) can interact with CD300LF,which was recently identified as a physiological receptor for MNoV.17 CD300LF is a member of the immunoglobulin superfamily.18,19. Here, CD300LF is linked to infection.