These KO BV-2 cells constitute cell models for X-linked adrenoleukodystrophy (X-ALD, MIM 300100), the most common peroxisomal disorder, which is linked to mutations in the ABCD1 gene (Mosser et al., 1993; Trompier and Savary, 2013; Kemp et al., 2016), and for a rarer disease, ACOX1-deficiency (MIM264470) (Poll-The et al., 1988; Ferdinandusse et al., 2007). Here, ACOX1 is linked to X-linked adrenoleukodystrophy.