The transplantation of pancreatic islets for the treatment of Type 1 Diabetes (T1D) is an important example and has been the focus of significant research efforts for several decades.[2,3] Successfully engrafted islet transplants can produce insulin in a glucose-responsive manner, and, in some cases, reduce or eliminate insulin dependence and hypoglycemic events entirely. The gene discussed is INS; the disease is type 1 diabetes mellitus.