Studies performed by Iżykowska et al. (2013, 2017) identified a variety of chromosomal rearrangements and copy number changes in Sézary syndrome affecting regions 6q23-27, 8q, 17p, 10q, 2p, 11q, and 9p, with altered expression of genes including, EHD1, MTMR2, RNF123, TOX, and TMEM244 - which was further indicated to be crucial for CTCL cell growth (Rassek et al., 2023b). This evidence concerns the gene TOX and Sezary syndrome.