Selected genes were identified to be involved in deregulated key signaling pathways, including cytokine-cytokine receptor interaction (IL7R, CXCL8, ACVR1C), hematopoietic cell lineage (IL7R), PI3K-Akt signaling pathway (COL4A6, IL7R, PGF), pathways in cancer (IL7R, CXCL8, PGF), Ras signaling pathway (PGF), MAPK signaling pathway (PGF), JAK-STAT signaling pathway (IL7R), transcriptional misregulation in cancer (CXCL8), and NOD-like receptor signaling pathway (CASP4). The gene discussed is COL4A6; the disease is cancer.