Although the direct relationship between acetylationlevels and ketone supplementation in this experiment is not fully demonstrated,a mouse model with hyperacetylation, created by double knockout of carnitineacetyltransferase and sirtuin 3, showed that hyperacetylation of the cardiacmitochondrial proteome has minimal impact on mitochondrial function or thesusceptibility of mice to stress-induced heart failure[206]. Here, SIRT3 is linked to heart failure.