Inline with the crucial role of SRCs in regulating energy metabolism in partthrough peroxisome proliferator-activated receptors, germline TIF2 KO miceare resistant to high-fat diet-induced obesity with enhanced adaptivethermogenesis, whereas SRC1 KO mice are more susceptible to obesity due todecreased energy expenditure[133]. Here, NCOA1 is linked to obesity due to melanocortin 4 receptor deficiency.