Consistent with this, ectopicexpression of a mutant Tip60 lacking KAT activity impairs DNA repair and theapoptotic response to γ-irradiation-induced DNA damage incells[41].Comparative analysis reveals significantly lower expression of Tip60 in lungadenocarcinoma relative to normal lung tissues, highlighting its importancein lung cancer tumorigenesis[39]. This evidence concerns the gene KAT5 and lung carcinoma.