Therefore, considering these THs effects in the molecular clockwork machinery and the increased hypothyroidism prevalence in women, this study aimed to evaluate the rhythmicity of the jejunum clockwork machinery (Bmal1, Per2, Cry1, and Nr1d1) and transporters involved in the macronutrient absorption (L-FABP, FATP4, MTTP, CD36, NPC1L1, PEPT1, NHE3, GLUT5, and GLUT2) in female mice under control and hypothyroid conditions, looking for a possible explanation for the increased risk of metabolic syndrome development in hypothyroid women, as observed in population studies. Here, SLC27A4 is linked to hypothyroidism.