Furthermore, in a nested case–control study involving 566 patients aged 70 and older undergoing major non-cardiac surgery, Dillon et al. confirmed that elevated preoperative and postoperative CRP levels were closely associated with the occurrence of delirium, which suggests that CRP can serve as an early predictive marker for postoperative delirium in elderly surgical patients, aiding in the identification of high-risk individuals and the implementation of preventive measures (13). This evidence concerns the gene CRP and delirium.