BMI: body mass index; CLBBB: complete left bundle branch block; CRBBB: complete right bundle branch block; IVCD: intraventricular conduction delay; CKD: chronic kidney disease (estimated glomerular filtration rate <50%); ICD: implantable cardioverter-defibrillator; LVEF: left ventricular ejection fraction; GLS: global longitudinal strain; ACE: angiotensin-converting enzyme inhibitor; ARB: angiotensin II receptor blocker; ARNI: angiotensin receptor neprilysin inhibitor. The gene discussed is ACE; the disease is chronic kidney disease.