MVMR mediation analysis identified specific immune cell types potentially driving pathways: CD40 on monocytes, CD45 on CD33+HLA-DR+CD14- for Bifidobacterium kashiwanohense, CD45 on CD33-HLA-DR+ for GCA-900066755 sp900066755, Terminally Differentiated CD4+T cell for Geminocystis, CD40 on monocytes, Central Memory CD4+T cell, CD28 on CD28+CD45RA+CD8+T cell for Saccharofermentanaceae and CRC. The gene discussed is CD4; the disease is colorectal carcinoma.