IL2 and pachyonychia congenita: In this paper, we will explore the structural features and functional properties of IL-2 family members and outline their roles and their molecular mechanisms in pancreatitis and PC, in order to deepen the understanding of the mechanisms of IL-2 family roles in pancreatic diseases and to lay a solid scientific foundation for the development of innovative therapeutic strategies for IL-2 family cytokines in pancreatic diseases.