Notably, the combination of PD-1/PD-L1 inhibitors with CT was associated with an increased risk of hypertension relative to the control group (RR = 1.953, 95% CI: 1.134-3.366; 95% PI: 0.053-69.830, I2 = 0%) (Table 3). The gene discussed is CD274; the disease is Hypertension.