MYD88 and TNF receptor 1-associated periodic fever syndrome: Their results showed that pretreatment with SCO inhibited the expression of TLR4/Myd88 and suppressed the phosphorylation of p38, ERK1/2 and cJun N-terminal kinase (JNK) as well as the activation of NF-κB in mice with D-galactosamine(D-GalN)/LPS-induced FHF (37).