KLRC2 and neoplasm: Indeed, adaptive NKG2C+CD57+NKG2A– self iKIR+ FcεRγ–/low NK cells showed high degranulation levels in response to IgG-opsonized tumor cells (Rituximab-coated Raji), after expansion with mAb and IL-2 or IL-15 (Figures 4C, D and representative experiment in Supplementary Figure S4).