Among these epitopes, the most immunogenic epitope, M1129-142, with the amino acid sequence GLIYNRMGAVTTEV, was able to stimulate an increased production of cognate CD4+ T cells in culture and showed stronger avidity for human leukocyte antigen (HLA) multimers across all donors compared to the well-studied HLA class II influenza epitope HA306-318-PKY (21). The gene discussed is CD4; the disease is influenza.