LEP and obesity due to melanocortin 4 receptor deficiency: This inflammation is potentially harmful to both body cells and brain function and has been linked to accelerate brain ageing.10,11 Unfortunately, in this study, data on GH, IGF-1, cytokines, leptin and haemoglobin A1c (HbA1c) were not available, limiting our ability to differentiate the effects of obesity and DHEAS on brain structures independent of these potential confounding factors.