This inflammation is potentially harmful to both body cells and brain function and has been linked to accelerate brain ageing.10,11 Unfortunately, in this study, data on GH, IGF-1, cytokines, leptin and haemoglobin A1c (HbA1c) were not available, limiting our ability to differentiate the effects of obesity and DHEAS on brain structures independent of these potential confounding factors. This evidence concerns the gene GH1 and obesity due to melanocortin 4 receptor deficiency.