A study on Chinese patients with stroke or TIA showed that the RNF213 p.Arg4810Lys variant is associated with LAA, anterior circulation ICAS, and ECAS.30 Another study on Japanese participants reported that the RNF213 p.Arg4810Lys variant was associated with a smaller external diameter of the carotid artery compared to the GG genotype,31 suggesting some impact on the carotid artery. Here, RNF213 is linked to stroke disorder.