RNF213 and familial isolated congenital asplenia: RNF213 p.Arg4810Lys was significantly associated with ICAS-only, ECAS-only, and concurrent ICAS and ECAS (aOR, 10.08; 95%CI, 1.28–79.13; P = 0.007, aOR, 10.56; 95%CI, 1.33–83.59; P = 0.026, and aOR, 32.75; 95%CI, 4.02–267.12; P < 0.001, respectively) (Supplemental Table 5).