RNF213 and coronary artery disorder: In multiple regression analysis, max-IMT was associated with age (β = 0.348, P < 0.0001), sex (β = 0.179, P < 0.0001), RNF213 p.Arg4810Lys (β = 0.179, P < 0.0001), history of coronary artery disease (β = 0.124, P = 0.007), and smoking (β = 0.127, P = 0.011) (Table 4).