Among different stroke subtypes, MMD and LAA were significantly associated with RNF213 p.Arg4810Lys (aOR, 77.55; 95%CI, 9.56–628.76; P< 0.001, aOR, 14.55; 95% CI, 4.41–48.05; P < 0.001, respectively). The gene discussed is RNF213; the disease is Stroke.