RNF213 and stroke disorder: In the sub-analysis, intracranial artery stenosis-only, extracranial artery stenosis-only, and concurrent intracranial artery stenosis and extracranial artery stenosis groups were significantly associated with RNF213 p.Arg4810Lys, regardless of stroke type (adjusted odds ratio, 3.72; 95% confidence interval, 1.30–10.60; P= 0.014, adjusted odds ratio, 7.04; 95% confidence interval, 1.51–32.77; P= 0.013, adjusted odds ratio, 11.68; 95% confidence interval, 4.25–32.07; P 0.001, respectively).