Maximum intima-media thickness (max-IMT) is an index of arteriosclerosis in ECAS.12 A small number of studies have reported the genetic factors associated with max-IMT, such as endothelin receptor type A (EDNRA, rs17612742).1 However, the association between RNF213 p.Arg4810Lys and max-IMT has not been reported. This evidence concerns the gene EDNRA and arteriosclerosis.