Association analysis with risk factors showed that max-IMT was affected by age (β = 0.324, P < 0.0001), sex (β = 0.173, P < 0.0001), RNF213 p.Arg4810Lys (β = 0.195, P < 0.0001), history of hypertension (β = 0.139, P = 0.005), history of diabetes (β = 0.176, P < 0.0001), history of hyperlipidaemia (β = 0.187, P < 0.0001), history of renal dysfunction (β = 0.142, P = 0.007), peripheral artery disease (β = 0.105, P = 0.034), history of coronary artery disease (β = 0.230, P < 0.0001), and smoking (β = 0.180, P < 0.0001). The gene discussed is RNF213; the disease is Abnormal renal physiology.