Proximal colon cancers, specifically, have a more aggressive clinical course and poorer prognosis; however, in our case, good clinical response to surgery and adjuvant therapy was noted. The genetic instability caused by the WRN mutation likely contributed to the patient's susceptibility to this malignancy, as WS patients often have defects in both homologous recombination and mismatch repair systems, exacerbating their risk for gastrointestinal cancers [2]. The gene discussed is WRN; the disease is malignant colon neoplasm.