A pathogenic variant, c.1105C>T (p.Arg369), that was identified in WRN led to the genetic instability associated with her mutated WRN protein likely contributing to the development of multiple malignancies including urothelial carcinoma, BCC, TNBC, colonic adenocarcinoma, and pancreatic IPMN. The gene discussed is WRN; the disease is urothelial carcinoma.