For example, a combination of four messenger RNA biomarkers, Kirsten rat sarcoma viral oncogene homolog, methyl-CpG binding domain protein 3-like 2, acrosomal vesicle protein 1, and dolichyl-phosphate mannosyltransferase subunit 1 (KRAS, MBD3L2, ACRV1, and DPM1), found in saliva can differentiate pancreatic cancer patients from non-cancer subjects [32,33]. This evidence concerns the gene MBD3L2 and familial pancreatic carcinoma.