RPL39 and pulmonary arterial hypertension: PV-LOOP results showed that RPL39 knockdown significantly increased the right ventricular end-systolic and Ved and mitigated the abnormal increase in right ventricular systolic capacity in male PAH rats, while RPL39 knockdown only significantly increased the right ventricular Ves in PAH female rats (Figures 5(a) and 5(b)).