5.VHL syndrome is a dominant familial genetic disease, with lesions covering the central nervous system, retinal hemangioblastoma, visceral tumors (especially renal cancer, adrenal phaochromocytoma), pancreatic cysts, multiple renal cysts, etc. The diagnosis of this disease can be confirmed by detecting the mutation of VHL gene. Here, VHL is linked to von Hippel-Lindau disease.