Because OPRCC is characterized by papillary structure, abundant eosinophilic plasma, and chromosomal triploid changes, Clinical diagnosis needs to be differentiated from clear renal cell carcinoma eosinophilic renal cell carcinoma, chromophobe renal cell carcinoma, type II PRCC and RO, MiT family translocation renal cell carcinoma, fumarate hydratase deficient renal cell carcinoma (FH-d RCC) and other renal cell carcinoma subtypes. This evidence concerns the gene FH and MIT family translocation renal cell carcinoma.