In combination with these diseases reported by several researchers (2–5), the author concluded that the immunophenotypic characteristics of OPRCC were positive for RCC (+) and AMACR (P504S) (strongly expressed in the papillary region and weakly expressed in the eosinophilic region), and low proliferative indices of Vimentin (+), CK10 (+/-) and Ki-67 (5%-10% +). This evidence concerns the gene AMACR and renal cell carcinoma.