These findings indicate that PD reduced OGD/R‐induced apoptosis in HT22 cells, and its neuroprotective effects may be related to the regulation of hub genes (PTGS2, HMOX1, SERPINE1, and ICAM‐1) as well as the JAK3/STAT3/HIF‐1α signaling pathway. Here, ICAM1 is linked to Parkinson disease.