MLST8 and cancer: Previous studies have shown that upregulation of mLST8 induces the activation of both mTORC1 and mTORC2 in multiple cell types (Saxton and Sabatini 2017), simultaneously leading to deficits in melanin biosynthesis, melanosome development, and metabolic abnormalities in cancer and skin pigmentation diseases (Guertin et al. 2006; Kakumoto et al. 2015).