Through PubMed, Medline, and Web of Science, this narrative review searched all the studies on GPM6A and tumors/cancers up to September 2024, and summarized the role of GPM6A in CRC, lung cancer, liver cancer, GB, and other malignant tumors, and made a summary of the relevant mechanisms for further researches. The gene discussed is GPM6A; the disease is lung carcinoma.