VWF and infective endocarditis: In the ROC curve analysis, the three thrombus components that exhibited a significant difference between IE and control thrombi in the univariable comparison (RBC, vWF, NETs morphology), along with thrombus histological age, displayed good AUC values, ranging between 0.846 and 0.953, in discriminating infective endocarditis (IE) and control thrombi.