We observed no significant associations between the presence of at least one APOE-ε4 allele and the ADRD signature, neither in the sample for dementia analyses (β 0.008 [ ± standard error (SE) 0.015], p-value 0.63), nor in the sample for analyses on cognitive assessment (β 0.007 [ ± SE 0.016], p-value 0.68). This evidence concerns the gene APOE and dementia.