NRG4 and metabolic dysfunction-associated steatohepatitis: Studies involving Nrg4 gain and loss of function in mice have conclusively shown that Nrg4 prevents diet-induced insulin resistance and hepatic steatosis by inhibiting adipogenic changes in hepatocytes [28], and it also alleviates the progression of non-alcoholic steatohepatitis by reducing the expression of inflammatory liver genes [35].