ALK and neuroblastoma: For children in the high-risk group, other drugs might be added as well, and some drugs might be given at higher doses.156 Recently, a two hits rational dual strategy was proposed to more efficiently counter neuroblastoma,157 where a chimeric antigen receptor (CAR)-T cell treatment appears more efficient by increasing the cell surface expression of the CAR target structure via a small molecule.158–160 CAR-T cells targeting anaplastic lymphoma kinase (ALK), which is frequently highly expressed on the surface of neuroblastoma cells, eliminate the tumor cells.