FOXO1 and glioma: In aggressive high-grade gliomas (pHGG), overexpression is controlled by histone methylation epigenetic alterations.146–152 In alveolar rhabdomyosarcoma, overexpression is via the PAX3-FOXO1 pioneer transcription factors gene fusion (Fig. 2).88,153 TRIB3 silencing promotes the downregulation of the AKT pathway and PAX3-FOXO1 in high-risk rhabdomyosarcoma.154