Aggressive cancers are also manipulated by strong activating mutations in proteins upstream in major proliferation pathways, such as receptor tyrosine kinases (RTKs), constitutively contributing vast numbers of active molecules.12–15 Spatial single-cell transcriptomics16,17 support the expectation that over time, over- (for suppressors, under-) expression vandalizes the signaling networks, vacating cellular controls, amplifying dedifferentiation thus heterogeneity. Here, NTRK1 is linked to cancer.