Mutations in epigenetic factors are frequent in hematological malignancies.276,277 Lower expression of EZH2 and chromosomal translocations leading to MLL-fusion proteins activate HOXA9 expression through dysregulated chromatin modification.278 Fusion with nuclear pore complex protein NUP98 and overexpression of CDX2 and CDX4 further upregulate HOXA9.276 Thus, AML’s overexpressed transcription factors, and its altered epigenetic landscape and associated transcriptomic program not only harness an embryonic transcriptional development program. Here, HOXA9 is linked to acute myeloid leukemia.