EMD and Hutchinson-Gilford progeria syndrome: As previously reported4,23, we confirmed the accumulation of the NE protein emerin into the cytoplasm of both NGPS1 and 2 (Fig. 1B), and the absence of lamin B1 downregulation (Fig. 1B) and of DNA double strand breaks accumulation (53BP1 foci Fig. 1C, D), both of which being common hallmarks of HGPS cells.