In view of the strong skeletal abnormalities of NGPS patients, it is also worth highlighting that our screen identified two genes involved in osteoclast development: LRRK1 (Leucine-rich repeat serine/threonine-protein kinase 1) and PAFAH1B1/LIS1 (Platelet-activating factor acetylhydrolase IB subunit alpha), whose depletion improve NGPS cellular phenotypes (Figs. 3 and 5) and in the case of LIS1 also increases viability of NGPS worms (Fig. 7C). The gene discussed is PAFAH1B1; the disease is Nestor-Guillermo progeria syndrome.