We hypothesize, therefore, that lower expression of these genes could confer a risk for the development and progression of aortic root dilatation and aortic dissection in women with TS, especially as loss of FBN1 is found in Marfan Syndrome where thoracic aortic aneurysm can be a key feature38. This evidence concerns the gene FBN1 and thoracic aortic aneurysm.