We established three stable isogenic VNTR6-1 knockout clones (V6.1-KO) in UMUC3, a bladder cancer cell line with high TERT expression (DepMap transcripts per million (TPM) = 6.78; Fig. 2a and Supplementary Fig. 7a, b) and two clones in A549, a lung cancer cell line with moderate TERT expression (TPM = 3.63, Supplementary Fig. 8a). Here, TERT is linked to lung cancer.