Using primary hepatocytes from control and Mc3rTB/TB mice, we found that under serum starvation, 4E-BP1 phosphorylation at Thr37/46 (indicative of MTORC1 activation) was clearly inhibited in both control and Mc3r defective hepatocytes (Supplementary Fig. 7a). The gene discussed is EIF4EBP1; the disease is tuberculosis.