Transgenic mouse models of thyroid cancer usually use a ubiquitously expressed thyroid gene (e.g., Tg or Tpo) as a Cre driver for targeted oncogene activation, which inevitably involves the majority of cells and thus deviates much from the sporadic and presumed monoclonal nature of PTC tumorigenesis (25). The gene discussed is TG; the disease is thyroid gland carcinoma.