More importantly, CA1001 appeared to be efficacious in preventing and treating a histone-induced "TTP-like" syndrome in Adamts-13 null mice, demonstrated by the alleviation of thrombocytopenia, prerenal injury, and formation of microvascular thrombosis in major organ tissues.<h4>Conclusion</h4>CA1001 can effectively inhibit VWF-platelet interaction and thrombus formation under various (patho)physiological conditions. Here, VWF is linked to Thrombocytopenia.