H2AX and chronic myelogenous leukemia, BCR-ABL1 positive: ,35,57,58 In mice, heterozygosity of Bcl11b promotes clonal expansion and differentiation arrest in murine thymocytes30 in part by an increase of β-catenin, and an acquired loss of H2AX was shown to induce blast crisis of chronic myelogenous leukemia.59