Subsequently, western blot analysis further showed that treatment with both IHCH9033 and MGCD0103 resulted in a significant decrease in the phosphorylation of FLT3 and its downstream targets, AKT, STAT5 and ERK, but this effect was observed only in FLT3-ITD AML cells (Fig. 2c, d). Here, AKT1 is linked to acute myeloid leukemia.