Notably, pS396-tau-positive RBPMS+ RGC counts were significantly elevated in MCI (2.1-2.3-fold; P < 0.05 − 0.01) and further increased in AD (2.9-4.1-fold; P < 0.01-0.0001) retinas, compared to CN controls, across retinal subregions and in the total ST region (Fig. 3i, j). This evidence concerns the gene MAPT and Alzheimer disease.