PS396-tau+ RGCs in the central and mid-periphery showed the closest associations with disease status, while Oligo-tau+ RGCs in the mid-periphery exhibited the strongest correlations with brain pathology (NFTs, Braak stages, ABC scores; rS=0.78–0.81, P < 0.001–0.0001) and cognitive decline (MMSE; rS=-0.79, P = 0.0019). This evidence concerns the gene MAPT and Mental deterioration.