Notably, RBPMS+ RGCs in these patients exhibited granulovacuolar degeneration (GVD) bodies marked by CHMP2B [130] and expressed the GVD-necroptotic marker pMLKL [61], suggesting that RGCs in early and advanced AD patients undergo cell death via GVD-mediated necroptosis. The gene discussed is RBPMS; the disease is Alzheimer disease.