Immunohistochemistry of the GVD marker, charged multivesicular body protein 2B (CHMP2B), commonly detected in brain neuronal GVDs [130], revealed prominent CHMP2B expression in RBPMS+ RGCs of MCI and AD patients, including in hypertrophic RGCs (Fig. 2h, white arrows). Here, CHMP2B is linked to Alzheimer disease.