CD4 and cancer: Using supervised and marker-based approaches [37], we annotated specific cell subpopulations: CD4+ T cells (n = 17,109), CD8+ T cells (n = 7,699), B cells (n = 2,538), monocytes (n = 6,595), dendritic cells (DCs) (n = 2,608), natural killer (NK) cells (n = 4,569), cancer-associated fibroblasts (n = 677), perivascular-like cells (n = 35), endothelial cells (n = 360), and other cell types (n = 2,452) (Fig. 3A and Table S3).