We also identified pleural effusion predictive gene signatures, including TMPRSS3, MS4A7, NAPSA, and IGFBP2, while liver metastasis predictive markers included WFDC2, HSPB1, COX6C, APOE, and TUBA1A (Fig. 2M). The gene discussed is IGFBP2; the disease is Pleural effusion.