LP liver metastasis cells had higher expression of genes linked to extracellular exosomes promoting EMT and metastasis, such as S100A8, EIF3H, LDHA, PPA1, and ENO1. They also showed upregulation of RPL/RPS family genes (previously identified in breast tumor metastases to the brain [55]) and proliferation-associated genes, such as TUBB, compared to BL (Figs. 2I and S2C and Table S2). This evidence concerns the gene S100A8 and breast neoplasm.