Significantly higher levels of exhaustion genes [42], including lymphocyte-activation gene 3 (LAG3), granulysin (GNLY), T cell immunoreceptor with Ig and ITIM domains (TIGIT), and TNF in T cells were found in BL than in EP and LP cells (Fig. 4M), indicating the potential benefit of blockade of novel immune checkpoint receptors LAG3 and TIGIT for BL patients. This evidence concerns the gene LAG3 and Burkitt lymphoma.