TNF and Burkitt lymphoma: Significantly higher levels of exhaustion genes [42], including lymphocyte-activation gene 3 (LAG3), granulysin (GNLY), T cell immunoreceptor with Ig and ITIM domains (TIGIT), and TNF in T cells were found in BL than in EP and LP cells (Fig. 4M), indicating the potential benefit of blockade of novel immune checkpoint receptors LAG3 and TIGIT for BL patients.