HTR5A and major depressive disorder: ECT [13] and atypical antidepressants such as nefazodone and bupropion have similarly been shown to enhance REM Time in MDD [51, 52]; in contrast, other antidepressants such as tricyclic antidepressants (TCAs), monoamine oxidase inhibitors (MAOIs), selective 5-hydroxytryptamine (5-HT), and SSRIs have been shown to decrease REM sleep as part of their antidepressant effects [53].