KDM5D and neoplasm: Taking advantage of the fact that the cells injected for xenograft assays were labelled with luciferase (Fig. 5e) we noted that KDM5C mutant tumours showed a non-significant trend to metastasise less frequently to the lungs than control 786-O cells and co-mutation of KDM5D in KDM5C mutant tumours restored the frequency of lung metastatic spread to a similar level to sgCtrl cells (Fig. 5f).