KDM5D mutation-specific up-regulated genes participate in epithelial-mesenchymal transition, interferon response and importantly include 8 potential tumour suppressor genes (IFI44L, DLG4, STRA6, GPRC5C, PTK7, NPTXR, BRINP1, SPINT1), while several genes involved in cell-cell signalling including growth-factor receptors FGFR3 and PDGFRB are down-regulated in these cells (Fig. 6d). This evidence concerns the gene SPINT1 and neoplasm.