KDM5C and neoplasm: The group with low Y chromosome gene expression in KDM5C wild-type tumours represented approximately 40% of the cases, similar to the previously reported frequency of loss of the Y chromosome in ccRCC17,18 while depending on the gene, between 12 and 16 of the 17 total (71–94%) KDM5C mutant tumours showed low Y chromosome gene expression.