Analyses of exome sequencing data from 41 single biopsies of primary ccRCC tumours in females revealed that 3 tumours harboured KDM5C mutations and showed concomitant loss of the X chromosome but an additional 6 tumours that harboured deletions of KDM5C due to loss of part or all of the X chromosome did not show mutations in KDM5C18. Here, KDM5C is linked to nonpapillary renal cell carcinoma.