To investigate whether KDM5C affects gene transcription by directly regulating gene promoters or enhancers we focused further analyses on A498 cells as this cell line is female, avoiding potential complications of KDM5D function, and since we showed that KDM5C functions as a tumour suppressor in A498 cells in the context of the xenograft assay. The gene discussed is KDM5C; the disease is neoplasm.