We reasoned that genes that were specifically dysregulated as a result of KDM5C, KDM5D or KDM5C/KDM5D mutation might also be dysregulated in KDM5C mutant human male ccRCC tumours, which also appear to have lost the Y chromosome and KDM5D function, however, this was not observed (Supplementary Fig. 4a–c). This evidence concerns the gene KDM5D and neoplasm.