KDM5D and nonpapillary renal cell carcinoma: Exome-sequencing19 (Fig. 1a) identified that the 786-O, CAKI-2 and SLR22 male human ccRCC cell lines show no KDM5C or KDM5D mutations and that the female A498 and 769-P cell lines also have wild type KDM5C. RCC4 cells exhibit a KDM5C frameshift deletion as previously described20.