In contrast to K562 cells, the BCR-ABL positive KU812 CML cell line was intrinsically hypersensitive to IM; SenB had no significant effect on the already very high apoptotic fraction in cells treated with IM alone (Fig. 1C, right, Supplementary Fig. S1). The gene discussed is ABL1; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.