Additionally, molecular profiling of lung adenocarcinoma has identified a high frequency of mutations in the tumor suppressors serine threonine kinase 11 (STK11–17%) and Kelch-like ECH associated protein 1 (KEAP1 - 17%), based on the analysis of 230 samples from the TCGA database (4). This evidence concerns the gene KEAP1 and lung adenocarcinoma.