Among them, RAS-RAF-ERK signaling, which is often activated in cancers, has been intensively investigated for its critical roles in regulating c-Myc expression at the transcriptional and post-translational levels, such as by elevating c-Myc mRNA expression and phosphorylating c-Myc at Ser62 to prevent its proteasomal degradation (57). The gene discussed is MYC; the disease is cancer.