CD8A and neoplasm: The positive association between ICB response and Ms to CD8 communication in the pre-treatment samples (i.e., higher arc count for responders, 0.0155 vs. 0.0092) could be justified by a significantly higher relative abundance of M1 (anti-tumor) to M2 (pro-tumor) polarized Ms in the responders (Wilcoxon rank-sum test; p = 0.018 comparing M2/M1 ratio in responders vs. non responders) (Figure S5D).