SCN1B and apraxia: As an example of the ADR-DP proteins identified in our study, the phenotype dyspraxia (MedDRA: 10009696) was associated with six proteins: three sodium channels (SCN1A, SCN9A, SCN1B) for action potential propagation, and three GABAA receptor subunits (GABRB3, GABRG2, GABRA6) for synaptic transmission (Figures 1D; Table S2).