In the human eye, the expression of canonical senescence markers such as p16, p21, and p53 has been documented in the retinal pigment epithelium (RPE) during aging (Chaum, Winborn, and Bhattacharya 2015) and in age‐related macular degeneration (AMD) (Lee et al. 2021; Sreekumar, Hinton, and Kannan 2020). This evidence concerns the gene TP53 and age-related macular degeneration.