AKT1 and cancer: In cancer cell lines, SGC-7901 and MGC-803, harmine was able to induce apoptosis through regulation of mitochondrial-mediated Akt/mTOR/p70S6K pathway and autophagy (adenosine 5’-monophosphate-activated protein kinase) pathway which is in turn linked to its ability to modulate cell microtubule protein light chain 3 (LC3-II), Beclin-1, and P62.