To further characterise the properties and distribution of CD8 + T cells, we used multiplex chromogenic IHC to stain CD3 in combination with CD8, together with 4G8 for Aβ plaques and Iba1 for microglia in some CTL and AD hippocampal samples (CTL n = 3; AD n = 6). This evidence concerns the gene CD8A and Alzheimer disease.