To our knowledge, CoM have not been described in any mouse models of AD, amyloid or tau, but a study by Beckman and colleagues showed a clear association between engulfing microglia and tangle-positive neurons specifically in the CA1 subfield in macaques injected with a dual tau mutation (P301L/S320F) arguing for a specific vulnerability of this neuronal population, at least in primates [7]. The gene discussed is MAPT; the disease is Alzheimer disease.