MAPT and Alzheimer disease: Memory-related brain regions are particularly affected by atrophy, neuronal and synaptic loss, neuroinflammation and high burdens of extracellular amyloid-β (Aβ) plaques and intraneuronal hyperphosphorylated tau (pTau) neurofibrillary tangles (NFTs), the latter two being the neuropathological hallmarks of AD.