Co-occurrence with other misfolded protein pathologies, such as phosphorylated α-synuclein (pSyn) typical of Parkinson’s disease (PD), or TAR DNA-binding protein 43 (TDP-43), found in pathological deposit in amyotrophic lateral sclerosis (ALS) or frontotemporal dementia (FTD) is frequently observed [29, 36, 54, 55, 57, 69, 73]. The gene discussed is TARDBP; the disease is frontotemporal dementia.