In FFPE sections, we observed a PCSK9 expression in neurons both in CTL and AD (Supplementary Fig. 7); however, in AD samples, PCSK9 staining was also associated with plaque microenvironments and with cells resembling PaM astrocytes in hippocampus and entorhinal cortex (Fig. 6D, E, Supplementary Fig. 7). The gene discussed is PCSK9; the disease is Alzheimer disease.