AIF1 and Alzheimer disease: Using confocal and STED microscopy, we confirmed the enrichment of this peculiar type of Iba1- accumulation in the CA1 and CA2 PL of AD hippocampi (Fig. 1C) and showed that they were spatially separated from 4G8-positive Aβ plaques (Fig. 1D–G, Supplementary Fig. 1A, B).