We then analysed the distribution of Proprotein convertase subtilisin/kexin type 9 (PCSK9) (n = 3 AD, 2 CTL) and Integrin subunit alpha 6 (ITGA6, also known as CD49f [6]) (n = 5 AD, 5 CTL), associated with the PaM astrocytes and PI3K-Akt pathways in our previous analysis. The gene discussed is PCSK9; the disease is Alzheimer disease.