DMG single-cell RNAseq data showed PRKACA, and AKT1 were expressed preferentially in malignant cells while PAK2 was also present in the immune and oligodendrocytic populations (Supplementary Figure 2c) suggesting targeting PAK2 can lead to off-tumor toxicity but PRKACA and AKT1 may be more selective targets. The gene discussed is PRKACA; the disease is neoplasm.