In the view of these, we finally revealed that the new mechanism of ischemic stroke treatment of SPRC is associated with the CBS/H2S/CD24/Iκ‐Bα/NF‐κB inflammatory pathway (Figure 11) and CBS/H2S/CD24/Src/Fak/Pyk2 migration pathway (Figure 12). This evidence concerns the gene SPRR3 and ischemic stroke.