SPRC reduces inflammation in ischemic stroke by regulating the CD24/Iκ‐Bα/NF‐κB inflammatory signaling pathway and improves the migration ability of M2 microglia via CD24/Src/Fak/Pyk2 signaling pathway, which further alleviates the inflammatory response at the lesion. This evidence concerns the gene SPRR3 and ischemic stroke.